If your well-being is in danger, it's probably wise to employ more than just one option in dealing with it, or at least take multiple options into consideration.
This is absolutely true. Real self defense systems are layered. They must address multiple situations, and multiple levels of force. A real defensive system should include weapons training, empty hand training, weapons retention, grappling, use of force training, etc.
A lot of self defense is about strategy as much as technique. And the strategies must take into consideration what your personal requirements are. Are you an LE professional, are you in the military and on the front line? Are you doing executive protection or are you a civilian who just needs some capability just in case?
What many men mean when they say they want to be able to defend themselves is that they want to be able to hang at their local bar or pub and not worry about getting beaten up. Is it really worth taking all the time, money and effort which martial arts training requires just to be able to do that? Or would it be simpler not to hang around in places like that?
You know where Aikido really shines in terms of real world application? Low level force restraint for law enforcement, corrections, and security personnel and weapons retention for anyone carrying a firearm (or other weapon) That's where dojo training most directly applies to some real world application.
Most civilians have little need for low level force restraint capability. Women have almost none. Almost any defensive situation a typical civilian might encounter would be at a threat level in which high level impact techniques or deadly force would be appropriate. Facing a threat of a certain level and responding at an insufficiently low level of force can be disastrous. That's why Aikido, which largely focuses on lower level force application, is not a great art as the foundation for a layered self defense system. Study something that teaches you how to take someone out, fast and violently, then add Aikido to give you some options. I'd have firearms as part of that system unless that was simply impossible for legal reasons and if I couldn't I'd have a couple layers of weapons capability, maybe even if I could.